本课题组现有职工3人（其中研究员1人、实验师2人）和在读研究生4人（其中博士研究生2人、硕士研究生2人）。

课题组研究方向为从传统中药和民间药物中寻找新的生物活性成分，阐明天然药物的活性作用物质基础，研究开发具有科学依据的现代天然药物，并为创新药物研究发现先导化合物。

 本课题组在进行天然产物提取分离和结构鉴定工作过程中，注重采用基于信息分析的生物活性跟踪分离方法、基于HPLC-DAD-MS的去重复（dereplication）分析方法和基于仪器自动化的天然产物纯化方法，以提高生物活性化合物的发现效率。

本课题组在进行天然产物提取分离和结构鉴定工作过程中，注重采用基于信息分析的生物活性跟踪分离方法、基于HPLC-DAD-MS的去重复（dereplication）分析方法和基于自动化仪器的天然产物纯化方法，以提高生物活性化合物的发现效率，并通过化学合成方法对所发现的生物活性成分进行结构优化和进一步成药性评估。此外，课题组还承担一些制药企业的中药有效部位化学成分分析、对照品制备、化学合成品杂质分析和民间验方、秘方功效成分分析的合同研究。

1. Selective cyclooxygenase-2 inhibitors from Calophyllum membraneceum. J Zou, DZ Jin, WL Chen, J Wang, QF Liu, XZ Zhu, WM Zhao. Journal of Natural Products, 2005, 68, 1514-1518.
2. Periplocoside E, an effective compound from Periploca sepium Bge, inhibited T cell activation in vitro and in vivo. YN Zhu, WM Zhao, YF Yang, QF Liu, Y Zhou, J Tian, J Ni, YF Fu, XG Zhong, W Tang, R Zhou, PL He, XY Li, JP Zuo. Journal of Pharmacology and Experimental Therapeutics, 2006, 662-669.
3. Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia.WL Chen, WD Tang, LG Lou, WM Zhao. Phytochemistry, 2006,1041-1047.
4. New guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica. WL Chen, QF Liu, J Wang, J Zou, DH Meng, JP Zuo, XZ Zhu, WM Zhao. Planta Medica, 2006, 143-150.
5. Alkyl phloroglucinol derivatives from Syzygium levinei and their differentiation-inducing activity. J Zou, Y Mi, LG Lou, WM Zhao. Planta Medica, 2006, 533-538.
6. Cytotoxic germacrane-type sesquiterpenes, pimarane-type diterpenes, and a naphthalene derivative from Wollastonia biflora. WL Chen, WD Tang, RJ Zhang, LG Lou, WM Zhao. Journal of Natural Products, 2007, 70, 567-570.
7. Sulfur-containing spiroketal glycosides from Breynia fruticosa. DH Meng, WL Chen, WM Zhao. Journal of Natural Products, 2007, 70, 824-829.
8. Anti-Helicobacter pylori and thrombin inhibitory components from Chinese Dragon’s Blood, Dracaena cochinchinensis. YD Zhu, P Zhang, HP Yu, J Li, MW Wang, WM Zhao. Journal of Natural Products, 2007, 70, 1570-1577.
9. Novel bis(bibenzyl) and (propylphenyl)bibenzyl derivatives from Dendrobium nobile. QF Liu, WL Chen, WM Zhao. Helvetica Chimica Acta, 2007, 90, 1745-1750.
10. Antibacterial phenolic components from Eriocaulon buergerianum. JJ Fang, G Ye, WL Chen, WM Zhao. Phytochemistry, 2008, 1279-1286.
11. Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions. J Wan, YN Zhu, JQ Feng, HJ Chen, RJ Zhang, J Ni, ZH Chen, LF Hou, QF Liu, J Zhang, L Yang, W Tang, YF Yang, FJ Nan, WM Zhao, JP Zuo. International Immunopharmacology, 2008, 1248-1256.
12. Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening. LG Lin, H Xie, HL Li, LJ Tong, CP Tang, CQ Ke, QF Liu, LP Lin, MY Geng, HL Jiang, WM Zhao, J Ding, Y Ye. Journal of Medicinal Chemistry, 2008, 51, 4419-4429.
13. Cytotoxic dihydroagarofuranoid sesquiterpenes from the seeds of Celastrus orbiculatus. YD Zhu, ZH Miao, J Ding, WM Zhao. Journal of Natural Products, 2008, 71, 1005-1010.
14. Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida. X Ge, G Ye, P Li, WJ Tang, JL Gao, WM Zhao. Journal of Natural Products, 2008, 71, 227-231.
15. High-throughput screening of novel antagonists on melanin-concentrating hormone receptor-11. JH Yan, QY Li, JA Boutin, MP Renard, YX Ding, XJ Hao, WM Zhao, MW Wang. Acta Pharmacologica Sinica, 2008, 29, 752-758.
16. Cucurbitane-type triterpenoids from the stems of Cucumis melo. C Chen, SG Qiang, LG Lou, WM Zhao. Journal of Natural Products, 2009, 72, 824-829.
17. New dihydrochalcone glycosides from Lithocarpus litseifolius and the phenomenon of C-H→C-D exchange observed in NMR spectra of phenolic components. ZH Chen, RJ Zhang, J Wu, WM Zhao. Journal of Asian Natural Products Research, 2009, 11, 508-513.
18. A new monoterpene-coumarin and a new monoterpene-chromone from Gerbera delavayi. SZ Liu, JQ Feng, J Wu, WM Zhao. Helvetica Chimica Acta, 2010, 93, 2026-2029.
19. Glycosides from Breynia fruticosa and Breynia rostrata. DH Meng, J Wu, WM Zhao. Phytochemistry, 2010, 71, 325-331.
20. Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca. LY Wang, ZH Chen, Y Zhou, W Tang, JP Zuo, WM Zhao. Phytochemistry, 2011, 72, 2230-2236.

 课题组目前主要的实验装备包括HPLC-DAD-MS、自动化制备型HPLC、MPLC和冷冻干燥机等。

研究室组织结构	岳建民研究组/叶　阳研究组/ 秦国伟研究组 /郭跃伟研究组/
	赵维民研究组/谭昌恒研究组