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经皮新剂型与新技术:包括化学药物/中药有效成分经皮新剂型与新技术,经皮疫苗给药研究。
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生物技术药物输送系统研究:包括生物材料的合成,新型给药系统的设计与制备,载体与大分子药物的相互作用,载体给药系统与生物屏障的相互作用,生物大分子黏膜给药研究,以及大分子药物靶向给药研究。
配备有较为齐备的现代药物制剂及给药系统研究设施,主要包括:全自动溶出仪、透皮扩散仪、高效液相色谱仪、快速蛋白液体色谱、热重分析仪、荧光光度计、多功能酶标仪、冷冻干燥器、真空干燥机、冷冻离心机,以及细胞培养设备。
近三年研究论文:
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Y Wang, EG Liu, XY Sun, P Huang, H Long, H Wang,YZ Huang*. Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs,Polymer Chemistry, 2013, online, DOI: 10.1039/C3PY00042G
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YZ Huang*, YF Jiang, HY Wang, JX Wang, HN He, V Yang*. Curb Challenges of the "Trojan Horse" Approach: Smart Strategies in Achieving Effective yet SafeCell-penetrating Peptide-based Drug Delivery,Advanced Drug Delivery Reviews, 2013, online. DOI: 10.1016/j.addr.2012.11.007
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L Yan, HY Wang, YF Jiang, JH Liu, Z Wang, YX Yang, SW Huang,YZ Huang*. Cell-penetrating Peptide-modified PLGA Nanoparticles for Enhanced Nose-to-brain Macromolecular Delivery,Macromolecular Research, 2013, online, DOI: 10.1007/s13233-013-1029-2
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HN He, A David, B Chertok, A Cole, K Lee, J Zhang, JX Wang,YZ Huang, V Yang*. Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-called Theranostic System.Pharmaceutical Research, 2013, online. DOI: 10.1007/s11095-013-0982-y
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YJ Sun, WB Dong, HY Wang,YZ Huang*, HK Gu, V Yang*, J Gong*. Template Synthesis of PMAA@Chitosan Hollow Nanorods for Docetaxel Delivery.Polymer Chemistry. 2013, 4, 2489-2495
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JH Liu, YX Zhao, Q Guo, Z Wang, HY Wang, YX Yang,YZ Huang*, TAT-modified Nanosilver for Combating Multidrug-resistant Cancer.Biomaterials, 2012, 33(26),6155-6161
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M Shen,YZ Huang, LM Hana, J Qin, V Yang, JX Wang*. Multidisciplinary drug delivery system for targeting tumor and its acidic microenvironment.Journal of Controlled Release. 2012, 161(3), 884-892
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YS Park, A David,YZ Huang, J Park, HN He, Y Byun, V Yang*. In vivo delivery of cell permeable antisense-HIF1a-oligonucleotide to adipose tissue reduces adiposity in obese mice.Journal of Controlled Release. 2012, 161(1), 1-9
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YX Yang, YF Jiang, Z Wang, JH Liu, L Yan, JX Ye,YZ Huang*. Skin-permeable Quaternary Nanoparticles with Layer-by-layer Structure Enabling Improved Gene Delivery.Journal of Material Chemistry, 2012, 22, 10029-10034
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JX Wang,YZ Huang, A David, B Chertok, L Zhang, FQ Yu, V Yang*. Magnetic nanoparticles for brain tumors imaging.Current Pharmaceutical Biotechnology. 2012, 13(12), 2403-2416
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S Wang, H Wang, WQ Liang*,YZ Huang*. An Injectable Hybrid Nanoparticle-in-Oil-in-Water Submicron Emulsion for Improved Delivery of Poorly Soluble Drugs.Nanoscale Research Letters, 2012, 7, 219
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SY Dong, S Wang, CH Zheng, WQ Liang*,YZ Huang*. An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics.Soft Matter, 2012, 7(12), 5873-5878
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YX Yang, Y Gao, LL Chen,YZ Huang*, YP Li*. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles.International Journal of Pharmaceutics. 2011, 405(1), 186-195
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YZ Huang, YF Rao, JL Chen, V Yang*, WQ Liang. Polysorbate cationic synthetic vesicle for gene delivery.Journal of Biomedical Materials Research - Part A. 2011, 96A(3), 513-519
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HN He, A David, J Zhang, YS Park, JX Wang,YZ Huang, JK Wang, V Yang. Low molecular weight protamine/insulin formulation with potential to attenuate protamine-masqueraded insulin allergy.Macromolecular Research, 2011, 19(12), 1224-1226
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YZ Huang, YS Park, C Moon, A David, HS Chung, V Yang*. Synthetic skin-permeable proteins enabling needleless immunization.Angewandte Chemie International Edition, 2010, 49(15), 2724-2727,
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YZ Huang, FQ Yu, YS Park, JX Wang, MC Shin, HS Chung, V Yang*. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery.Biomaterials. 2010, 31(34), 9086-9091,
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FQ Yu, L Zhang,YZ Huang, A David, V Yang*, The magnetophoretic mobility and superparamagnetism of core-shell iron oxide nanoparticles with dual targeting and imaging functionality.Biomaterials. 2010, 31(22), 5842-5848,
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YS Park,YZ Huang, YJ Park, A David, L White, HN He, HS Chung, V Yang*. Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1á-oligonucleotide.Journal of Controlled Release. 2010, 144(1), 82-90,
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XL Zheng,YZ Huang, CH Zheng*, SY Dong, WQ Liang. Alginate-Chitosan-PLGA composite microspheres enabling single-shot hepatitis B vaccination.The AAPS Journal. 2010, 12 (4), 519-524,
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YZ Huang, YS Park, JX Wang, C Moon, YM Kwon, HS Chung, V Yang*. ATTEMPTS system: a macromolecular prodrug strategy for cancer drug delivery.Current Pharmaceutical Design. 2010, 16 (21), 2369-2376
承担课题情况
1.国家自然科学基金重大研究计划(91029743 )(主持)
2.国家自然科学基金面上项目(81172996 )(主持)
3.上海市浦江人才计划(主持)
4.复旦大学智能化递药教育部及全军重点实验室开放课题(主持)
5. 中国博士后基金面上项目(一等) (王慧媛博士))
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