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谢欣研究组
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谢欣研究组
谢欣研究员

    

  课题组成立于 2006 年,现有职工9人,研究生6人,联合培养研究生3人,共计18人。

    

    

  谢欣研究员主要从事基于G蛋白偶联受体(GPCR)的新药发现及干细胞化学生物学研究,聚焦在以下几个方向:

  1、GPCR在重大疾病中的作用及其机制研究,以及药理学干预;

  2、GPCR新药筛选平台的建设及新药发现;

  3、干细胞命运调控小分子的发现、机制研究及在疾病中的应用。

  

 

  1. Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie*. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Research. 2012, Oct 9. doi: 10.1038/cr.2012.143. [Epub ahead of print].
  2. Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie*. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. Journal of Biological Chemistry.2012 Aug 17; 287(34):28656-65. Epub 2012 Jun 25.
  3. Chang-Sheng Du, Xin Xie*. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012 Jul; 22(7):1108-28. Epub 2012 Jun 5.
  4. Lixin Cui, Jing Li, Xin Xie*. Rediocide A, an Insecticide, Induces G-Protein-Coupled Receptor Desensitization via Activation of Conventional Protein Kinase C. Journal of Natural Products.2012 Jun 22; 75(6):1058-62. Epub 2012 May 31.
  5. Ru Zhang, Guizhen Xue, Shaodeng Wang, Lihong Zhang, Changjie Shi, Xin Xie*. Novel object recognition as a facile behavior test for evaluating drug effects in APP/PS1 Alzheimer’s mouse model. Journal of Alzheimers Disease. 2012, 31: 801-812. Epub 2012 Jun 18.
  6. Ru Zhang, Xin Xie*. Tools for GPCR Drug Discovery. Acta Pharmacologica Sinica. 2012 Mar; 33(3):372-84. Epub 2012 Jan 23.
  7. Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie*. Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 2011;187(5):2336-45.
  8. Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie*. Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells. Cell Research. 2011;21(10):1424-35.
  9. Chenlei Yin, Ru Zhang, Yongyu Xu, Qiuyan Chen, Xin Xie*. Intact Mdm2 E3 Ligase Activity Is Required for the Cytosolic Localization and Function of β-Arrestin2. Molecular Biology of the Cell. 2011 Mar 9; 22(9):1608-16.
  10. Jing Li, Shuyong Zhang, Linghuan Gao, Ying Chen, and Xin Xie*. A cell-based high-throughput assay for the screening of small molecule inhibitors of p53-MDM2 interaction. Journal of Biomolecular Screening. 2011 Apr;16:450-456.
  11. Wu G, Xie X, Lu ZH, Ledeen RW. Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum.Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10829-34.(IF=9.771)
  12. He X, Fang L, Wang J, Yi Y, Zhang S, Xie X*. Bryostatin-5 blocks SDF-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Research 2008 Nov 1; 68(21):8678-86.   

  研究室组织结构

  

  

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