国重头模板--新药研究国家重点实验室
2015年度发表论文目录
作者:管理员      发表日期: 2016-12-09作者:管理员      发表日期: 2016-12-09作者:管理员      发表日期: 2016-12-09作者:管理员      发表日期: 2016-12-09作者:管理员      发表日期: 2016-12-08         打印    【 】  【关闭

 

  1. K Polyacetylenes of Marine Origin: Chemistry and Bioactivity

Zhou ZF, Marialuisa Menna, Cai YS and Guo YW*

Chem. Rev. (2015)115: 1543-1596 46.56

  1. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Kang YY, X.Edward Zhou, Gao X, He YZ, Liu W, Andrii Ishchenko, Anton Barty, Thomas A. White, Oleksandr Yefanov, GyeWon Han, Xu QP, Parker W. deWaal, Ke JY, M. H. Eileen Tan, Zhang CH, Arne Moeller, Graham M. West8, Bruce D. Pascal, Ned Van Eps, Lydia N. Caro, Sergey A. Vishnivetskiy, Regina J. Lee, Kelly M. Suino-Powell1, Gu X, Kuntal Pal, Ma JM, Zhi XY, Se´bastien Boutet, Garth J. Williams, Marc Messerschmidt, Cornelius Gati, Nadia A. Zatsepin, Wang DJ, Daniel James, Shibom Basu, Shatabdi Roy-Chowdhury, Chelsie E. Conrad, Jesse Coe, Liu HG, Stella Lisova, Christopher Kupitz, Ingo Grotjohann, Raimund Fromme, Jiang Y, Tan MJ, Yang HY, Li J, Wang MT, Zheng Z, Li DF, Nicole Howe, Zhao YM, Jo¨rg Standfuss, Kay Diederichs, Dong YH, Clinton S. Potter, Bridget Carragher, Martin Caffrey, Jiang HL, Henry N. Chapman, John C. H. Spence, Petra Fromme, Uwe Weierstal, Oliver P. Ernst, Vsevolod Katritch, Vsevolod V. Gurevich, Patrick R. Griffin, Wayne L. Hubbel, Raymond C. Stevens, Vadim Cherezov, Karsten Melcher and H. Eric Xu*

Nature (2015)523: 561-567 41.456

  1. Structural insight into substrate preference for TET-mediated oxidation

Hu LL, Lu JY, Cheng JD, Rao QH, Li Z, Hou HF, Lou ZY, Zhang L, Li W, Gong W, Liu MJ, Sun C, Yin XT, Li J, Tan XS, Wang PC, Wang YS, Fang D, Cui Q, Yang PY, He C, Jiang HL, Luo C* and Xu YH*

Nature (2015)527: 118-122 41.456

  1. Probing disease-related proteins with fluorogenic composite materials

He XP, Zang Y, Tony D. James, Li J* and Chen GR*

Chem. Soc. Rev. (2015)44: 4239-4248 33.383

  1. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Wang J, Luo C, Shan CL, You QC, Lu JY, Elf SN, Zhou Y, Wen Y, Jan L. Vinkenborg, Fan J, Heebum Kang, Lin RT, Han DL, Xie YX, Jason Karpus, Chen SJ, Ouyang SS, Luan CH, Zhang NX, Ding H, Maarten Merkx4, Hong Liu2, Chen J*, Jiang HL* and He C*

Nat.Chem. (2015)7: 968-979 25.325

  1. Phainanoids A−F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis

Fan YY, Zhang H, Zhou Y, Liu HB, Tang W, Zhou B, Zuo JP and Yue JM*

J. Am. Chem. Soc. (2015)137: 138-141 12.113

  1. Rhodium(I)-Catalyzed Asymmetric Carbene Insertion into B−H Bonds: Highly Enantioselective Access to Functionalized Organoboranes

Chen D, Zhang X, Qi WY, Xu B and Xu MH*

J. Am. Chem. Soc. (2015)137: 5268-5271 12.113 

  1. Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Wang TL, Hong , Huang Y, Su HM, Wu F, Chen Y, Wei L, Huang W, Hua XL, Xia Y, Xu JL, Gan JH, Yuan BF, Feng YQ, Zhang, Yang CG* and Zhou X*

J. Am. Chem. Soc. (2015)137: 13736-13739 12.113

  1. pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

Yu HJ*, Cui ZR, Yu PC, Guo CY, Feng B, Jiang TY, Wang SL, Yin Q, Zhong DF, Yang XL, Zhang ZW and Li YP*

Adv. Funct. Mater. (2015)25: 2489-2500 11.805 

  1. Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer

He XY, Bao XY, Cao HQ, Zhang ZW*, Yin Q, Gu WW, Chen LL, Yu HJ and Li YP*

Adv. Funct. Mater. (2015)25: 2831-2839 11.805 

  1. Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects

Zhang XH, Zhou Y, Zuo JP and Yu B*

Nat. Commun. (2015)6: 5879 11.47 

  1. Conformational states of the full-length glucagon receptor

Yang LL, Yang DH, Chris de Graaf, Arne Moeller, Graham M. West, Venkatasubramanian Dharmarajan, Wang C, Fai Y. Siu, Song GJ, Steffen Reedtz-Runge, Bruce D. Pascal, Wu BL, Clinton S. Potter, Zhou H, Patrick R. Griffin, Bridget Carragher, Yang HY, Wang MW, Raymond C. Stevens and Jiang HL*

Nat. Commun. (2015)6: 7859 11.47

  1. c-Myc Alterations Confer Therapeutic Response and Acquired Resistance to c-Met Inhibitors in MET-Addicted Cancers

Shen AJ, Wang L, Huang M, Sun JY, Chen Y, Shen YY, Yang XY, Wang X, Ding J*

Cancer Res. (2015)75(21): 4548-4559 9.329

  1. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification

Sun WY, Xie ZQ, Liu YF, Zhao D, Wu ZX, Zhang DD, Lv H, Tang S, Jin N, Jiang HL, Tan MJ, Ding J, Luo C, Li J, Huang M and Geng MY*

Cancer Res. (2015)75(21): 4923-4936 9.329

  1. Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes

He XP*, Zhu BW, Zang Y, Li J*, Chen GR, Tian H and Long YT*

Chem. Sci. (2015)6: 1996-2001 9.211 

  1. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

Huang Y, Yan JL, Li Q, Li JF, Gong SZ, Zhou H, Gan JH, Jiang HL, Jia GF*, Luo C* and Yang CG*

Nucleic Acids Res. (2015)43(1): 373-384 9.112

  1. Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition

Kong XQ, Liu J, Li LC, Yue LY, Zhang LH, Jiang HL, Xie X* and Luo C*

Nucleic Acids Res. (2015)43(9): 4381-4392 9.112

  1. A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation

Lu JY, Jiang CX, Li XJ, Jiang LZ, Li ZX, Tilman Schneider-Poetsch, Liu JW, Yu KQ, Jun O. Liu, Jiang HL, Luo C* and Dang YJ*

Nucleic Acids Res. (2015)43(21): 10157-10167 9.112 

  1. Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel

Tang S, Yin Q*, Su JH, Sun HP, Meng QS, Chen Y, Chen LL, Huang YZ, Gu WW, Xu MH, Yu HJ, Zhang ZW and Li YP*

Biomaterials (2015)48: 1-15 8.557 

  1. Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer

Xu PF, Meng QS, Sun HP, Yin Q*, Yu HJ, Zhang ZW, Cao M, Zhang YZ and Li YP*

Biomaterials (2015)64: 10-20 8.557 

  1. Targeting PI3Kδ: Emerging Therapy for Chronic Lymphocytic Leukemia and Beyond

Wei MM, Wang X, Song ZL, Jiao MK, Ding J, Meng LH* and Zhang A*

Med. Res. Rev. (2015)35(4): 720-752 8.431

  1. In silico ADME/T modelling for rational drug design

Wang YL, Xing J, Xu Y, Zhou NN, Peng JL, Xiong ZP, Liu XA, Luo XM, Luo C, Chen KX, Zheng MY* and Jiang HL*

Q Rev. Biophys. (2015)48: 488-515 7.81

  1. Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression

Cao HQ, Zhang ZW*, Zhao S, He XY, Yu HJ, Yin Q, Zhang ZP, Gu WW, Chen LL and Li YP*

J. Control. Release (2015)205: 162-171 7.705 

  1. Near infrared light-actuated gold nanorods with cisplatin–polypeptide wrapping for targeted therapy of triple negative breast cancer

Feng B, Xu ZA, Zhou FY, Yu HJ*, Sun QQ, Wang DG, Tang ZH, Yu HY, Yin Q, Zhang ZW and Li YP*

Nanoscale (2015)7: 14854-14864 7.394

  1. Activatable nanoproes for biomolecular detection

Zhang PC, Andrew G Cheetham, Lye Lin Lock, Li YP and Cui HG*

Curr. Opin. Biotech. (2015)34: 171-179 7.117 

  1. Selective fluorogenic imaging of hepatocellular H2S by a galactosyl azidonaphthalimide probe

Shi DT, Zhou D, Zang Y, Li J*, Chen GR, Tony D. James, He XP* and Tian H

Chem. Commun. (2015)51: 3653-3655 6.834

  1. Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

Dong L, Zang Y, Zhou D, He XP*, Chen GR, Tony D. Jamesc and Li J*

Chem. Commun. (2015)51: 11852-11855 6.834

  1. Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts

Wang PP, Wei YJ, Fan Y, Liu QF, Wei W, Yang CS, Zhang L, Zhao GP, Yue JM*, Yan X* and Zhou ZH*

Metab. Eng. (2015)29: 97-105 6.767

  1. A Chemical Proteomics Approach for Global Analysis of Lysine Monomethylome Profiling

Wu ZX, Cheng ZY, Sun MW, Wan XL, Liu P, He TM, Tan MJ* and Zhao YM*

Mol. Cell. Proteomics. (2015): 329-339 6.564

  1. Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC* and Zhao YM*

Mol. Cell. Proteomics (2015)14(11): 3056-3071 6.564

  1. RhIII-Catalyzed Redox-Neutral C−H Activation of Pyrazolones: An Economical Approach for the Synthesis of N Substituted Indoles

Fan ZL, Song SS, Li W, Geng KJ, Xu YJ, Miao ZH* and and Zhang A*

Org. Lett. (2015)17: 310-313 6.364

  1. Rhodium-Catalyzed Asymmetric Arylation of Cyclic N Sulfonyl Aryl Alkyl Ketimines: Efficient Access to Highly Enantioenriched α Tertiary Amines

Jiang T, Wang Z and Xu MH*

Org. Lett. (2015)17: 528-531 6.364

  1. Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3 + 2] Cycloaddition from Carpesium abrotanoides

Wu JW, Tang CP, Chen L, Qiao Y, Geng MY and Ye Y*

Org. Lett. (2015)17: 1656-1659 6.364

  1. Phase Transfer Reagent Promoted Tandem Ring-Opening and Ring-Closing Reactions of Unique 3 (1-Alkynyl) Chromones

Liu Y, Jin SY, Huang LP and Hu YH*

Org. Lett. (2015)17: 2134-2137 6.364

  1. Phosphine-Catalyzed Aza-MBH Reactions of Vinylpyridines: Efficient and Rapid Access to 2,3,5-Triarylsubstituted 3 Pyrrolines

Chen J, Li JJ, Wang JZ, Li H*, Wang W* and Guo YW*

Org. Lett. (2015)17: 2214-2217 6.364 

  1. Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum

Liao HB, Lei C, Gao LX, Li JY, Li J and Hou AJ*

Org. Lett. (2015)17: 5040-5043 6.364

  1. Synthesis of Functionalized Chromeno[2,3-b]pyrrol-4(1H)-ones by Silver-Catalyzed Cascade Reactions of Chromones/Thiochromones and isocyanoacetates

Qi XY, Xiang HY and Yang CH*

Org. Lett. (2015)17: 5590-5593 6.364 

  1. Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa

Zhang H, Zhu KK, Han YS, Luo C, Mark A. Wainberg and Yue JM*

Org. Lett. (2015)17: 6274−6277 6.364 

  1. Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

Zhang J, He PX, Xi Y,Geng MY, Chen Y* and Ding J*

Oncotarget (2015): 2917 6.359 

  1. Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

Song XP, Zhao ZM, Qi X, Tang S, Wang Q, Zhu TJ, Gu QQ, Liu M* and Li J*

Oncotarget (2015)6(7): 5263-5274 6.359

  1. Dual Targeting of Microtubule and Topoisomerase II by α-Carboline Derivative YCH337 for Tumor Proliferation and Growth Inhibition

Yi JM, Zhang XF, Huan XJ, Song SS, Wang W, Tian QT, Sun YM, Chen Y, Ding J, Wang YQ*, Yang CH* and Miao ZH*

Oncotarget (2015)6(11): 8960-8973 6.359

  1. Tanshinone I Inhibits Tumor Angiogenesis by Reducing Stat3 Phosphorylation at Tyr705 and Hypoxia-induced HIF-1α Accumulation in both Endothelial and Tumor Cells

Wang Y, Li JX, Wang YQ* and Miao ZH*

Oncotarget (2015) 6(18): 16031-16042 6.359

  1. Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents

Lin C, Zeng H, Lu J, Xie Z, Sun W, Luo C, Ding J, Yuan S, Geng MY* and Huang M*

Oncotarget (2015)6(24): 20578-20591 6.359

  1. Characterization of Panax ginseng UDPGlycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts

Wei W, Wang PP, Wei YJ, Liu QF, Yang CS, Zhao GP, Yue JM*, Yan X* and Zhou ZH*

Mol. Plant (2015)8: 1412-1424 6.337

  1. Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles

Yu PC, Yu HJ*, Guo CY, Cui ZR, Chen XZ, Yin Q, Zhang PC, Yang XL*, Cui HG and Li YP*

Acta Biomater. (2015)14: 115-124 6.025

  1. Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against Sepsis

Hou JC, Chen QX, Zhang K, Cheng BL, Xie GH, Wu XL, Luo C, Chen LM, Liu H, Zhao B, Dai KZ and Fang XM*

Anesthesiology (2015)123: 409-422 5.879

  1. Alkylations of Arylboronic Acids including Difluoroethylation/
    Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction

Zhang XF and Yang CH*

Adv. Synth. Catal. (2015)357: 2721-2727 5.663

  1. Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe

He XP, Hu XL, Jin HY, Gan JM, Zhu HL*, Li J*, Long YT* and Tian H

Anal. Chem. (2015)87: 9078-9083 5.636

  1. Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth

Huang HJ, Liu HN, Liu CM, Fan LX, Zhang XW, Gao AH, Hu XB, Zhang KZ, Cao XC, Jiang KL, Zhou YB*, Hou J, Nan FJ and Li J

Cancer Lett. (2015)360: 257-268 5.621

  1. Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases

Zhang L, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y*, Ding JP* and Li J*

Sci. Rep. (2015)5: 10115 5.578

  1. Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms

Xu Y, Liu X, Wang YL, Zhou NN, Peng JL, Gong LK*, Ren J, Luo C, Luo XM*, Jiang HL, Chen KX and Zheng MY*

Sci. Rep. (2015)5: 13684 5.578

  1. Network modelling reveals the mechanism underlying colitisassociated colon cancer and identifies novel combinatorial anti-cancer targets

Lu JY, Zeng HL, Liang ZJ*, Chen LM, Zhang LY, Zhang H, Liu H, Jiang HL, Shen BR, Huang M*, Geng MY*, Sarah Spiegel* and Luo C*

Sci. Rep. (2015)5: 14739 5.57

  1. Migration of PIP2 lipids on voltagegated potassium channel surface influences channel deactivation

Chen LP, Zhang QS, Qiu YG, Li ZY, Chen ZX, Jiang HL, Li Y* and Yang HY*

Sci. Rep. (2015)119: 15079 5.578

  1. (Z)3,4,5,4 '-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

Fan XX, Yao XJ, Xu SW, Wong, Vincent Kam-Wai, He JX, Ding J, Xue WW, Mujtaba, Tahira; Michelangeli, Francesco, Huang M, Huang J, Xiao DK, Jiang ZB, Zhou YL, Kam Richard Kin-Ting, Liu L* and Leung, Elaine Lai-Han*

Sci. Rep. (2015)5: 16348 5.578

  1. Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases

Song ZL, Yang YH, Liu ZQ, Peng X, Guo JF, Yang XY, Wu K, Ai J*, Ding J, Geng MY* and Zhang A*

J. Med. Chem. (2015)58: 197-211 5.447

  1. Fragment-Based Drug Discovery of 2 Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based Optimization

Zhao LL, Wang YQ, Cao DY, Chen TT, Wang Q, Li YL, Xu YC, Zhang NX, Wang X, Chen DQ, Chen L, Chen YL, Xia GX, Shi Z, Liu YC, Lin YJ, Miao ZH*, Shen JK* and Xiong B*

J. Med. Chem. (2015)58: 1281-1297 5.447

  1. Design and Optimization of a Series of 1 Sulfonylpyrazolo[4,3 b]pyridines as Selective c Met Inhibitors

Ma YC, Sun GQ, Chen DQ, Peng X, Chen YL, Su Y, YC J, Liang J, Wang X, Chen L, Ding J, Xiong B*, Ai J*, Geng MY* and Shen JK*

J. Med. Chem. (2015)58: 2513-2529 5.447

  1. Quantum Chemistry Calculation-Aided Structural Optimization of Combretastatin A 4-like Tubulin Polymerization Inhibitors: Improved Stability and Biological Activity

Jiang JH, Zheng CH*, Zhu KK, Liu J, Sun NN, Wang CQ, Jiang HL, Ju Zhu*, Luo C* and Zhou YJ*

J. Med. Chem. (2015)58: 2538-2546 5.447

  1. Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes

Duan HL, Ning MM, Zou QG, Ye YL, Feng Y, Zhang LN, Leng Y* and Shen JH*

J. Med. Chem. (2015)58: 3315-3328 5.447

  1. Discovery and Optimization of Novel, Selective Histone
    Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening

Meng FW, Cheng SF, Ding H, Liu SE, Liu Y, Zhu KK, Chen SJ, Lu JY, Xie YQ, Li LJ, Liu RF, Shi Z, Zhou Y, Liu YC, Zheng MY, Jiang HL, Lu W*, Liu H* and Luo C*

J. Med. Chem. (2015)58: 8166-8181 5.447

  1. Discovery of a Novel Series of Imidazo[1,2 a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors

Chen XD, Xu WW, Wang K, Mo MG, Zhang W, Du LL, Yuan XJ, Xu YC, Wang YP* and Shen JH*

J. Med. Chem. (2015)58: 8529-8541 5.447

  1. Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area

Liu CL, Fang X, Wu QQ, Jin GZ and Zhen XC*

Neuropharmacology (2015)43: 299-308 5.106

  1. TarPred: a web application for predicting therapeutic and side effect targets of chemical compounds

Liu X, Gao Y, Peng JL, Xu Y, Wang YL, Zhou NN, Xing J, Luo XM, Jiang HL* and Zheng MY*

Bioinformatics (2015)31(12): 2049-2051 4.981

  1. Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxoneprecipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala

Wang WS, Chen ZG, Liu WT, Chi ZQ, He L and Liu JG*

Brit. J. Pharmacol. (2015)172: 482-491 4.842

  1. Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite

Ji DK, Zhang Y, Zang Y*, Liu W, Zhang XW, Li J*, Chen GR, James Tony D and He XP*

J. Mater. Chem. B. (2015)3(47): 9182-9185 4.726

  1. Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii

Xiong J, Hong ZL, Gao LX, Shen J, Liu ST, Yang GX, Li J*, Zeng HQ and Hu JF*

J. Org. Chem. (2015)21: 11080-11085 4.721

  1. Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409

Deng SS, Wu LY, Wang YC, Cao PR, Xu L, Li QR, Liu M, Zhang L, Jiang YJ, Yang XY, Sun SN, Tan MJ, Qian M, Zang Y*, Feng LY* and Li J*

J. Biol. Chem. (2015)290(5): 3149-3160 4.573

  1. AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms

Dai YL, Huang SL and Leng Y*

Int. J. Biol. Sci. (2015): 1272-1280 4.509 

  1. Codelivery of Sorafenib and Curcumin by Directed Self-Assembled Nanoparticles Enhances Therapeutic Effect on Hepatocellular Carcinoma

Cao HQ, Wang YX, He XY, Zhang ZW*, Yin Q, Chen Y, Yu HJ, Huang YZ, Chen LL, Xu MH, Gu WW and Li YP*

Mol. Pharmaceut. (2015)12: 922-931 4.384

  1. Inhibition of Breast Cancer Metastasis by Pluronic Copolymers with Moderate Hydrophilic−Lipophilic Balance

Sun HP, Meng QS, Tang S, Su JH, Yin Q, Chen LL, Gu WW,Yu HJ, Zhang ZW, Wang SL* and Li YP*

Mol. Pharmaceut. (2015)12: 3323-3331 4.384

  1. The role of the GABA system in amphetamine-type stimulant use disorders

Jiao DL, Liu Y, Li XH, Liu JG and Zhao M*

Front. Cell Neurosci. (2015)9: 162 4.289

  1. A copper-based layered coordination polymer: synthesis, magnetic properties and electrochemical performance in supercapacitors

Liu Q*, Liu XX, Shi CD, Zhang YP, Feng XK, Cheng ML, Su S and Gu JD*

Dalton T. (2015)44: 19175-19184 4.197

  1. P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity

Zhou PZ, Zhang YM, Xu HY, Chen F, Chen XQ, Li XY, Pi XP, Wang LP, Zhan L, Nan FJ* and Gao ZB*

Mol. Pharmacol. (2015)87: 31-38 4.128

  1. Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation

Wu YW, He SJ, Bai BX, Zhang LY, Xue L, Lin ZM, Yang XQ, Zhu FH, He PL, Tang W* and Zuo JP*

Cell. Mol. Imm. (2015): 1-12 4.112

  1. T he role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity

Li CZ, Xing GZ, Kazuya Maeda, Wu CY, Gong LK, Sugiyama, Qi XM*, Ren J and Wang GJ*

Toxicol. Res. (2015)4: 1260-1268 3.983

  1. Interaction Between DNA/histone Methyltransferases and their Inhibitors

J. Hu, S. Chen, X. Kong, K. Zhu, S. Cheng, M. Zheng, H. Jiang and Luo C*

Curr. Med. Chem. (2015)22: 360-372 3.853

  1. Structural diversity of terpenoids in the soft coral Sinularia flexibilis, evidenced by a collection from the South China Sea

Chen WT, Li J, Wang JR, Li XW* and Guo YW*

RSC Adv. (2015)5: 23973-23980 3.840

  1. Ricinodols A–G: new tetracyclic triterpenoids as 11b-HSD1 inhibitors from Ricinodendron heudelotii

Yu JH, Shen Y, Wu Y, Leng Y, Zhang H* and Yue JM*

RSC Adv. (2015)5: 26777-26784 3.840

  1. Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore

Jiang X, Wang MN, Song SS, Xu YJ*, Miao ZH* and Zhang A*

RSC Adv. (2015)5: 27502-27508 3.840

  1. Ga(OTf)3-promoted synthesis of functionalized 2- carbonyl-imidazo[1,2-α]pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate

Yang FX, An WT, Qian ZW, Yu T, Du YL, Ma LP, Wang X, Meng T* and Shen JK*

RSC Adv. (2015)5: 32015-32019 3.840

  1. Discovery of 4-benzoylpiperidine and 3-(piperidin-4-yl)benzo[d]isoxazole derivatives as potential and selective GlyT1 inhibitors

Liu Y, Guo L, Duan HL, Zhang LM, Jiang N, Zhen XC* and Shen JH*

RSC Adv. (2015)5: 40964-40977 3.840

  1. Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex

Giuseppina Chianese, Gu BB, Yang F, Jiao WH, Guo YW, Lin HW* and Orazio Taglialatela-Scafati*

RSC Adv. (2015)5: 63372-63376 3.840

  1. Synthesis of substituted pyrroles using a silver-catalysed reaction between isocyanoacetates/benzyl isocyanides and chromones

Qi XY, Xiang HY, Yang YH and Yang CH*

RSC Adv. (2015)5: 98549-98552 3.840

  1. Diterpene Alkaloids with an Aza-ent-kaurane Skeleton from Isodon rubescens

Liu X, Yang J, Wang WG, Li Y, Wu JZ, Pu JX* and Sun HD*

J. Nat. Prod. (2015)78: 196-201 3.798

  1. Hupehenols A-E, Selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors from Viburnum hupehense

Chen XQ, Shao LD, Pal Mahesh, Shen Y, Cheng X, Xu G, Peng LY, Wang K, Pan ZH, Li MM, Leng Y, He J* and Zhao QS*

J. Nat. Prod. (2015)78: 330-334 3.798 

  1. Limonoids and Triterpenoids from Dysoxylum mollissimum var. glaberrimum

Han ML, Zhao JX, Liu HC, Ni G, Ding J, Yang SP* and Yue JM*

J. Nat. Prod. (2015)78: 754-761 3.798

  1. Limonoids with Anti-HIV Activity from Cipadessa cinerascens

Yu JH, Wang GC, Han YS, Wu Y, Mark A. Wainberg and Yue JM*

J. Nat. Prod. (2015)78: 1243-1252 3.798

  1. Limonoids with 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum

Zhou B, Shen Y, Wu Y, Leng Y* and Yue JM*

J. Nat. Prod. (2015)78: 2116-2122 3.798

  1. Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa

Wu JW, Tang CP, Yao S, Zhang L, Ke CQ, Feng LY, Lin G and Ye Y*

J. Nat. Prod. (2015)78: 2332-2338 3.798

  1. New Hydroxylated Daphniphyllum Alkaloids from Daphniphyllum himalense

Zhang H, Sajan L. Shyaula, Li JY, Li J and Yue JM*

J. Nat. Prod. (2015)78(11): 2761-2767 3.798

  1. Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa

Zheng XM, Meng FW, Geng F, Qi M, Luo C, Yang L* and Wang ZT*

J. Nat. Prod. (2015)78(11): 2822-2826 3.798

  1. An Accurate Metalloprotein-Specific Scoring Function and Molecular Docking Program Devised by a Dynamic Sampling and Iteration Optimization Strategy

Bai F, Liao S, Gu JF, Jiang HL, Wang XC and Li HL*

J. Chem. Inf. Model. (2015)55: 833-847 3.738

  1. Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors

Zhang Y, Xu L, Zhang ZQ, Zhang ZY, Zheng LT, Li D, Li YY, Liu F, Yu KQ, Hou TJ* and Zhen XC*

J. Chem. Inf. Model. (2015)55(9): 1994-2004 3.738

  1. Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy

Dan ZL, Cao HQ, He XY, Zeng LJ, Zou LL, Shen Q* and Zhang ZW*

Int. J. Pharmaceut. (2015)483: 63-68 3.650

  1. A highly diastereoselective Friedel–Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles

Chen JP, Chen WW, Li Y and Xu MH*

Org. Biomol. Chem. (2015)13: 3363-3370 3.562

  1. Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

Zheng Y, Song WB, Zhang SW and Xuan LJ*

Org. Biomol. Chem. (2015)13: 6474-6478 3.562

  1. Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol

Wang TJ, Chen WW, Li Y and Xu MH*

Org. Biomol. Chem. (2015)13: 6580-6586 3.562

  1. An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes

Jiang M, Zhu FX, Xiang HY, Xu X, Deng LF* and Yang CH*

Org. Biomol. Chem. (2015)13: 6935-6939 3.562

  1. Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold

Liu J, Peng X, Dai Y, Zhang W, Ren SM, Ai J*, Geng MY* and Li YX*

Org. Biomol. Chem. (2015)13: 7643-7654 3.562

  1. Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-aminoindolo[1,2-a]quinazoline derivatives

Jiang M, Xiang HY, Zhu FX, Xu X, Deng LF* and Yang CH*

Org. Biomol. Chem. (2015)13: 10122-10126 3.562

  1. Directing-group-assisted copper-catalyzed oxidative esterification of phenols with aldehydes

Zheng Y, Song WB and Xuan LJ*

Org. Biomol. Chem. (2015)13: 10834-10843 3.562

  1. Blood pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced liver injury in humans

Ruan JQ, Gao H, Li N, Xue JY, Chen J, Ke CQ, Ye Y, Peter Pi-Cheng Fu, Zheng J, Wang JY* and Lin G*

J. Environ. Sci. Heal. C (2015)33(4): 404-421 3.56

  1. Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors

Zhang X, Kong YN, Zhang J, Su d, Zhou YB, Zang Y, Li J, Chen Y, Fang YF*, Zhang XW and Lu W*

Eur. J. Med. Chem. (2015)95: 127-135 3.447

  1. Enhancing the cellular anti-proliferation activity of pyridazinones as cmet inhibitors using docking analysis

Xing WQ, Ai J, Jin SY, Shi ZX, Peng X, Wang L, Ji YC, Lu D, Liu Y, Geng MY* and Hu YH*

Eur. J. Med. Chem. (2015)95: 302-312 3.447

  1. Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates

Cao XF, Xu YY, Cao YB, Wang RL, Zhou R, Chu WJ and Yang YS*

Eur. J. Med. Chem. (2015)102: 471-476 3.447

  1. Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities

Liu G, Song SS, Shu SQ, Miao ZH, Zhang A and Ding CY*

Eur. J. Med. Chem. (2015)103: 17-28 3.447

  1. Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: Design, synthesis, and structuredactivity relationship study

Jiang XL, Zhou J, Ai J*, Song ZL, Peng X and Xing L, Xi Y, Guo JF, Yao QZ*, Ding J, Geng MY* and Zhang A*

Eur. J. Med. Chem. (2015)105: 39-56 3.447

  1. Photoinduced Electron Detachment and Proton Transfer: The Proposal for Alternative Path of Formation of Triplet States of Guanine (G) and Cytosine (C) Pair

Gu JD*, Wang J and Jerzy Leszczynski*

J. Phys. Chem. B (2015)119: 2454-2458 3.302

  1. Two-Quartet G Quadruplexes Formed by DNA Sequences Containing Four Contiguous GG Runs

Qin MY, Chen ZX, Luo QC, Wen Y, Zhang NX, Jiang HL and Yang HY*

J. Phys. Chem. B (2015)119: 3706-3713 3.302

  1. Lactate Dehydrogenase B Is Associated with the Response to Neoadjuvant Chemotherapy in Oral Squamous Cell Carcinoma

Sun WY, Zhang XM, Ding X, Li HQ, Geng MY, Xie ZQ*, Wu HM* and Huang M*

PLOS ONE (2015): 125976 3.234

  1. Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons

Lei Y, Yang L, Ye: CY, Qin MY, Yang HY, Jiang HL, Tang XC and Zhang HY*

PLOS ONE (2015): 128366 3.234

  1. Exploring NAG-thiazoline and its derivatives as inhibitors of chitinolytic β-acetylglucosaminidases

Liu T, Xia M, Zhang HT, Zhou H, Wang J, Shen X and Yang Q*

FEBS Lett. (2015)589(1): 110-116 3.169

  1. Design and Synthesis of Novel Arctigenin Analogues for the Amelioration of Metabolic Disorders

Duan SD, Huang SL, Gong J, Shen Y, Zeng LM, Feng Y, Ren WM, Leng Y* and Hu YH*

ACS Med. Chem. Lett. (2015)6: 386-391 3.12

  1. HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes

Tan Hayden, Weng Siong, Sim Arthur Yi Loong, Huang SL, Leng Y and Long YC*

J. Mol. Endocrinol. (2015)55(3): 197-207 3.081

  1. Synthesis of Rigid Analogues of Flavone by Intramolecular Heck Reaction

Hou CW, Chen H, Xu X, Zhu FX, Guo L, Jiang M*, Yang CH* and Deng LF

Eur. J. Org. Chem. (2015): 3040-3043 3.065

  1. A One-Pot Copper(II)-Catalyzed Tandem Synthesis of 2-Substituted Pyrrolo[1,2-b]pyridazin-4(1H)-ones

Tan C, Xiang HY, He Q and Yang CH*

Eur. J. Org. Chem. (2015): 3656-3660 3.065

  1. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice

Yang XZ, Yang J, Xu C, Huang Mi, Zhou Q, Lv JN, Ma XH, Ke CQ, Ye Y, Shu GW* and Zhao P*

J. Ethnopharmacol. (2015)171: 161-170 2.998

  1. Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery

H Eric Xu*

Acta Pharmcol. Sin. (2015)36: 1-2 2.912

  1. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy

Li TT, Zhang XH, Jing JF, Li X, Yang XQ, Zhu FH, Tang W* and Zuo JP*

Acta Pharmcol. Sin. (2015)36: 188-199 2.912

  1. Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice

Zeng HL, Huang SL, Xie FC, Zeng LM, Hu YH* and Leng Y*

Acta Pharmcol. Sin. (2015)36: 343-352 2.912

  1. -(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

Zhang J, Zhang LN, Chen DM, Fu YY, Zhang F, Yang LL, Xia CM, Jiang HW, Tang CL, Xie ZF, Yang F, Li J, Tang J* and Li JY*

Acta Pharmcol. Sin. (2015)36: 483-496 2.912

  1. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells

Zhang HH, Kuang S, Wang Y, Sun XX, Gu Y, Hu LH and Yu Q*

Acta Pharmcol. Sin. (2015)36: 507-516 2.912

  1. Novel κ-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation

Zhang LS, Wang J, Chen JC, Tao YM, Wang YW, Xu XJ, Chen J, Xu YG, XI T, Hu XW*, Wang YJ* and Liu JG

Acta Pharmcol. Sin. (2015)36: 565-571 2.912

  1. High yield and efficient expression and purification of the human 5-HT3A receptor

Wu ZS, Cui ZC, Cheng H, Fan C, Karsten Melcher, Jiang Y, Zhang CH, Jiang HL, Cong Y, Liu Q* and H Eric Xu*

Acta Pharmcol. Sin. (2015)36: 1024-1032 2.912

  1. Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel

Zhang HZ, Xu XL, Chen HY, SherA li, Wang D, Yu JW, Xu T* and Nan FJ*

Acta Pharmcol. Sin. (2015)36: 1137-1144 2.912

  1. Toward rapamycin analog (rapalog)-based precision cancer therapy

Meng LH and XF Steven Zheng*

Acta Pharmcol. Sin. (2015)36: 1163-1169 2.912

  1. PI3K isoform-selective inhibitors: next-generation targeted cancer therapies

Wang X, Ding J* and Meng LH*

Acta Pharmcol. Sin. (2015)36: 1170-1176 2.912

  1. DCLAK11, a multi-tyrosine kinase inhibitor, exhibits potent antitumor and antiangiogenic activity in vitro

Guo XB, Zhu W, Peng XJ, Huang M, Liu HC, Liu H and Ding J*

Acta Pharmcol. Sin. (2015)36: 1266-1276 2.912

  1. Toll-like receptors: potential targets for lupus treatment

Wu YW, Tang W* and Zuo JP*

Acta Pharmcol. Sin. (2015)36: 1395-1407 2.912

  1. Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats

Ju YY, Long JD, Liu Y and Liu JG*

Acta Pharmcol. Sin. (2015)36: 1437-1443 2.912

  1. Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors

Zhou NN, Xu Y, Liu X, Wang YL, Peng JL, Luo XM, Zheng MY*, Chen KX and Jiang HL*

Int. J. Mol. Sci. (2015)16: 13407-13426 2.862

  1. Bioactive constituents from the green alga Caulerpa racemosa

Yang P, Liu DQ, Liang TJ, Li J, Zhang HY, Liu AH, Guo YW and Mao SC*

Bioorg. Med. Chem. (2015)23: 38-45 2.793

  1. Discovery and SAR study of c-Met kinase inhibitors bearing an 3-amino-benzo[d]isoxazole or 3-aminoindazole scaffold

Jiang XL, Liu HY, Song ZL, Peng X, Ji YC, Yao QZ*, Geng MY, Ai J* and Zhang A*

Bioorg. Med. Chem. (2015)23: 564-578 2.793

  1. Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists

Hu SW, Wang ZL, Hou TJ, Ma XD, Li J, Liu T*, Xie X* and Hu YZ*

Bioorg. Med. Chem. (2015)23: 1157-1168 2.793

  1. Synthesis and biological evaluation of 3-([1,2,4]triazolo [4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3 beta inhibitors and neuroprotective agents

Ye Q, Mao WL, Zhou YB, Xu L, Li Q, Gao YX, Wang J, Li CH, Xu YZ, Xu Y, Liao H, Zhang LY, Gao JR*, Li J* and Pang T*

Bioorg. Med. Chem. (2015)23: 1179-1188 2.793

  1. Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold

Song PR, Chen M, Ma XD, Xu L, Liu T*, Zhou YB* and Hu YZ*

Bioorg. Med. Chem. (2015)23: 1858-1868 2.793

  1. Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents

Wang L, Xie S, Ma LJ, Chen Y* and Lu W

Bioorg. Med. Chem. (2015)23: 1950-1962 2.793

  1. Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design

Du YL*, Ling H, Zhang M, Shen JK and Li QY*

Bioorg. Med. Chem. (2015)23: 4891-4898 2.793

  1. Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors

Yang W, Li LX, Wang YL, Wu XW, Li TT, Yang N, Su MB, Sheng L, Zheng MY, Zang Y, Li J* and Liu H*

Bioorg. Med. Chem. (2015)23: 5881-5890 2.793

  1. Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic

Liu PH, Du YL*, Song LH, Shen JK and Li QY*

Bioorg. Med. Chem. (2015)23: 7079-7088 2.793

  1. Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells

Wang AQ, Liu QY, Ye Y, Wang YT and Lin LG*

Food Funct. (2015)6(9): 3013-3021 2.791

  1. Palladium-catalyzed oxidative ortho-acylation of 2-arylbenzoxazoles and 2-arylbenzothiazoles with toluene derivatives

Zheng Y, Song WB, Zhang SW and Xuan LJ*

Tetrahedron (2015)71: 1574-1580 2.641

  1. Anti-HIV Securinega alkaloid oligomers from Flueggea virosa

Zhang H, Han YS, Mark A. Wainberg and Yue JM*

Tetrahedron (2015)71: 3671-3679 2.641

  1. A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells

Zhang X, Zhang L, Liu YQ, Bao B, Zang Y, Li J* and Lu W*

Tetrahedron (2015)71: 4842-4845 2.641

  1. NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor

Bao B, Liu M, Liu YQ, Zhang X, Zang Y, Li J* and Lv W*

Tetrahedron (2015)71: 7865-7868 2.641

  1. Diels-Alder adducts with PTP1B inhibition from Morus notabilis

Wang M, Gao LX, Wang J, Li JY, Yu MH, Li J and Hou AJ*

Phytochemistry (2015)109: 140-146 2.547

  1. Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors

Lv YC, Li MY, Cao SF, Tong LJ, Peng T, Wei LX, Xie H*, Ding J* and Duan WH*

MedChemComm (2015)15(6): 1375-1380 2.495

  1. C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant

Xu TF, Peng T, Ren XM, Zhang LW, Yu L, Luo JF, Zhang Z, Tu ZC, Tong LJ, Huang ZR, Lu XY, Geng MY, Xie H*, Ding J* and Ding K*

MedChemComm (2015)6: 1693-1697 2.495

  1. Discovery of New Non-Steroidal Farnesoid X Receptor Modulators Through 3D Shape Similarity Search and Structure-Based Virtual Screening

Wang L, Si P, Sheng YY, Chen YJ, Wan P, Shen X, Tang Y, Chen LL* and Li WH*

Chem. Biol. Drug Des. (2015)85: 481-487 2.485

150.Synthesis and Evaluation of 3-(furo[2,3-b]pyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as Novel GSK-3β Inhibitors and Anti-Ischemic Agents

Ye Q, Li Q, Zhou YB, Xu L, Mao WL, Gao YX, Li CH, Xu Y, Xu YZ, Liao H, Zhang LY, Gao JR*, Li J* and Pang T*

Chem. Biol. Drug Des. (2015)86:746-752 2.485

  1. Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B

Wang WL, Chen X, Gao LX, Sheng L, Li JY, Li J* and Feng BN*

Chem. Biol. Drug Des. (2015)86:1161-1167 2.485

  1. Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents

Jiang CS, Fu Y, Zhang L, Gong JX, Wang ZZ, Xiao W*, Zhang HY* and Guo YW*

Bioorg. Med. Chem. Lett. (2015)25: 216-220 2.42

  1. Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization

An XD, Liu HY, Xu ZL, Jin Y, Peng X, Yao YM*, Geng MY* and Long YQ*

Bioorg. Med. Chem. Lett. (2015)25: 708-716 2.42

  1. Multidrug resistance–reversal effects of resin glycosides from Dichondra repens

Song WB, Wang WQ, Zhang SW and Xuan LJ*

Bioorg. Med. Chem. Lett. (2015)25: 795-798 2.42

  1. PTP1B inhibitors from stems of Angelica keiskei (Ashitaba)

Li JL, Gao LX, Meng FW, Tang CL, Zhang RJ, Li JY, Luo C*, Li J* and Zhao WM*

Bioorg. Med. Chem. Lett. (2015)25: 2028-2032 2.42

  1. Synthesis and structure–activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents

Xue T, Ding S, Guo B*, Chu WJ, Wang H and Yang YS*

Bioorg. Med. Chem. Lett. (2015)25: 2203-2210 2.42

  1. Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors

Chen J, Gao LX, Gong JX, Jiang CS, Yao LG, Li JY, Li J*, Xiao W and Guo YW*

Bioorg. Med. Chem. Lett. (2015)25: 2211-2216 2.42

  1. Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold

Deng XX, Guo L, Xu LL, Zhen XC*, Yu KQ, Zhao WL* and Fu W*

Bioorg. Med. Chem. Lett. (2015)25: 3970-3974 2.42

  1. 2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFRL858R/T790M

ChanSP, Han K, Qu R, Tong LJ, Li YJ, Zhang Z, Cheng HM, Lu XY, Adam Patterson, Jeff Smaill, Ren XM, Ding J, Xie H* and Ding K*

Bioorg. Med. Chem. Lett. (2015)25: 4277-4281 2.42

  1. Effects of group housing on ECG assessment in conscious cynomolgus monkeys

Xing GZ, Lu J, Hu MM, Wang SD, Zhao L, Zheng WJ, Jason Schofield, Karen Oldman, Debbie Adkins, Marie South, Yu H, Ren J* and Matthew Skinner*

J. Pharmacol. Tox. Met. (2015)73: 44-51 2.39

  1. Sarcophytrols A–C, new capnosane diterpenoids from the South China Sea soft coral Sarcophyton trocheliophorum

Chen WT, Yao LG, Li XW* and Guo YW*

Tetrahedron Lett. (2015)56: 1348-1352 2.379

  1. Copper-catalyzed oxidative esterification of ortho-formyl phenols without affecting labile formyl group

Zheng Y, Song WB and Xuan LJ*

Tetrahedron Lett. (2015)56: 4569-4573 2.379

  1. Trinorcassane and cassane diterpenoids from the seeds of Caesalpinia minax

Zheng Y, Zhang SW and Xuan LJ*

Fitoterapia (2015)102: 177-181 2.345

  1. Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models

Guo DY, Li DW, Ning MM, Dang XY, Zhang LN, Zeng LM, Hu YH* and Leng Y*

Biochem. Biophy. Res. Co. (2015)466: 740-747 2.297

  1. Effects of ion interactions with a cholesterol-rich bilayer

Mao LX, Yang LL, Zhang QS, Jiang HL* and Yang HY*

Biochem. Biophy. Res. Co. (2015)468: 125-129 2.297

  1. Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel

Liu C, Chen ZQ, Zhong K, Li L, Zhu WL, Chen XY and Zhong DF*

Drug Metab. Dispos. (2015)43: 1632-1641 2.252

  1. (5R)-5-Hydroxytriptolide (LLDT-8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

Shen Y, Jiang T, Wang RS, He SJ, Guo MR, Zuo JP* and He DY*

BMC Complem. Altern. M. (2015) 15: 77 2.02

  1. Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage

Deng SS, Zhang C, Wang H, Zang Y*, Li J, He XP* and Chen GR

Carbohyd. Res. (2015)408: 114-118 1.929

  1. Lysophospholipids from the Guangxi Sponge Spirastrella purpurea

Lin K, Yang P, Yang H, Liu AH, Yao LG, Guo YW and Mao SC*

Lipids (2015) 50: 697-703 1.854

  1. Design, synthesis and biological evaluation of acylhydrazone derivatives as PI3K inhibitors

Gao GR, Liu JL, Mei DS, Ding J, Meng LH* and Duan WH*

Chinese Chem. Lett. (2015)26: 118-120 1.587

  1. Design, synthesis and biological evaluation of LpxC inhibitors with novel hydrophilic terminus

Ding S, Wang WK, Cao Q, Chu WJ, Lan LF, Hu WH and Yang YS*

Chinese Chem. Lett. (2015)26(6): 763-767 1.587

  1. Acidic rearrangement of benzyl group in flavone benzyl ethers and its regioselectivity

Wang CQ, Chen X, Jiang JH, Tang H, Zhu KK, Zhou YJ*, Zheng CH* and Zhu J*

Chinese Chem. Lett. (2015)26(6): 793-796 1.587

  1. Design, synthesis and biological evaluation of O-linked indoles as VEGFR-2 kinase inhibitors (I)

Gao GR, Li MY, Tong LJ, Wei LX, Ding J*, Xie H* and Duan WH*

Chinese Chem. Lett. (2015)26: 1165-1168 1.587

174.A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction

Zhang DQ, Xiao JF, Zhou NN, Zheng MY*, Luo XM*, Jiang HL* and Chen KX

BioMed Res. Int. (2015): 292683 1.579

  1. Prediction of Drug Indications Based on Chemical Interactions and Chemical Similarities

Huang GH, Lu Y, Lu CH, Zheng MY* and Cai YD*

BioMed Res. Int. (2015): 584546 1.579

  1. New Isoprenylated Phenolic Compounds from Morus laevigata

Wang M, Yu BW, Yu MH, Gao LX, Li JY, Wang HY, Li J and Hou AJ*

Chem. Biodiver. (2015)12: 937-945 1.515

  1. Bibenzyl and phenolic glycosides from Pterospermum heterophyllum

Li DX, Yin YP, Li J and Xuan LJ*

Phytochem. Lett. (2015)11: 220-223 1.45

  1. New acyclic sesquiterpenoid derivatives and a monoterpene disaccharide from Dichondra repens Forst.

Wang WQ and Xuan LJ*

Phytochem. Lett. (2015)14: 23-26 1.45

  1. Diterpenes and lignans from Viburnum odoratissimum var. odoratissimum

Li FJ, Yu JH, Wang GC, Zhang H* and Yue JM*

J. Asian Nat. Prod. Res. (2015)17: 475-481 0.913

  1. Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria

He WF, Liang LF, Cai YS, Gao LX, Li YF, Li J, Liu HL* and Guo YW*

J. Asian Nat. Prod. Res. (2015)17: 861-866 0.913

  1. Antibacterial triterpenoids from Melia toosendan

Zhu Q, Lin LG*, Tang CP, Ke CQ and Ye Y

Rec. Nat. Prod. (2015)9(2): 267-270 0.868

  1. Synthesis and Anticancer Activity of 7,8-dihydroxy-4-arylcoumarins

Wu JR, Peng T, Chen F, Leng YX, Tong LJ, Li MY, Qu R, Xie H, Ding J and Duan WH*

Lett. Drug. Des. Discov. (2015)12(5): 366-373 0.77

  1. Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis

Cui J, Wang XY, Li1 XH, Wang X, Zhang CL, Li W, Zhang YM, Gu HF, Xie X, Nan FJ*, Zhao J* and Pei G*

Cell Discov. (2015)1: 15021; doi:10.1038/celldisc.2015.21 新杂志

  1. FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells

Zhang LP, Shen AJ, Wang L, Liu HC, Chen DQ, Xiong B, Shen JK and Geng MY*

Oncoscience (2015)2(4): 419-427 新杂志

  1. Recent applications of chiral N-tert-butanesulfinyl imines, chiral diene ligands and chiral sulfur-olefin ligands in asymmetric synthesis

Dong HQ, Xu MH*, Feng CG, Sun XW and Lin GQ*

Org. Chem. Front. (2015)2: 73-89 新杂志

  1. HSP90 小分子抑制剂研究进展

任景,严碧波,石峰,熊兵,沈竞康*

药学学报Acta Pharmaceut. Sin. (2015)50 (6): 640-649 核心期刊

  1. 泽漆脂溶性成分的气相色谱-质谱联用分析

徐晶,张在龙,刘海利,郭跃伟

时珍国医国药 2015(1): 9-10 核心期刊

 

开放课题发表论文

  1. Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity

Zhang FY, Wang B, Pritesh Prasad, Robert J. Capon* and Jia YX*

Org. Lett. (2015)17: 1529-1532 6.364

189.Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKK beta-dependent AMPK activation

Xu Y, Xu YZ, Wang YR, Wang YJ, He L, Jiang ZZ, Huang ZJ, Liao H, Li J, Saavedra, Juan M, Zhang LY* and Pang T*

Brain Behav. Immun. (2015)50: 298-313 5.889

  1. A Dynamic View of ATP-coupled Functioning Cycle of Hsp90 N-terminal Domain

Zhang HQ, Zhou C, Chen WY, Xu YC, Shi YH, Wen Y* and Zhang NX*

Sci. Rep. (2015)5: 9542 5.578

  1. Construction of β Mannosidic Bonds via Gold(I)-Catalyzed Glycosylations with Mannopyranosyl ortho-Hexynylbenzoates and Its Application in Synthesis of Acremomannolipin A

Sun P, Wang P, Zhang YZ, Zhang XL, Wang C, LiuSJ, Lu JJ and Li M*

J. Org. Chem. (2015)80: 4164-4175 4.721

  1. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects

Ruan Z, Wang HM, Huang XT, Fu Y, Wu J, Ye CY, Li JL, Wu L, Gong Q, Zhao WM* and Zhang HY*

J. Neurochem. (2015)133: 93-103 4.281

  1. Separation and characterization of phenolic compounds and triterpenoid saponins in licorice (Glycyrrhiza uralensis) using mobile phase-dependent reversed-phase x reversed-phase comprehensive two-dimensional liquid chromatography coupled with mass spectrometry

Qiao X, Song W, Ji S, Wang Q, Guo DA and Ye M*

J. Charomatogr. A. (2015)1402: 36-45 4.169

  1. Formal [4 + 1] cycloaddition of o-quinone methides: facile synthesis of dihydrobenzofurans

Lei XT, Jiang CH, Wen XA, Xu QL* and Sun HB*

RSC Adv. (2015)5: 14953-14957 3.840

  1. Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Ji S, Qiao X, Li ZW, Wang YR, Yu SW, Liang WF, Lin XH and Ye M*

RSC Adv. (2015)5: 45258-45265 3.840

  1. Comprehensive chemical analysis of triterpenoids and polysaccharides in the medicinal mushroom Antrodia cinnamomea

Qiao X, Song W, Wang Q, Liu KD, Zhang ZX, Bo T, Li RY, Liang LN, Tzeng YM*, Guo DA and Ye M*

RSC Adv. (2015)5: 47040-47052 3.840

  1. Natural β-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus

Ning RN, Lei Y, Liu SZ, Wang HA, Zhang RJ, Wang W, Zhu YD, Zhang HY* and Zhao WM*

J. Nat. Prod. (2015)78(11): 2175-2186 3.798

  1. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction

Gao YX, Xu XJ, Chang S, Wang YJ, Xu YZ, Ran SQ, Huang ZJ, Li P, Li J, Zhang LY, Saavedra, Juan M., Liao H* and Pang T*

Toxicol. Appl. Pharm. (2015)289(2): 142-154 3.705

  1. Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth

Wang J, Peng YQ, Liu Y, Yang J, Ding N and Tan WF*

BMC Cancer (2015)15: 595 3.362

  1. Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats

Deng YP, Yang M, Xu F, Zhang Q, Zhao Q, Yu HT, Li DF, Zhang G, Lu AP, Cho KK, Teng FK, Wu P, Wang LL, Wu WY, Liu X, Guo DA and Jiang BH*

PLOS ONE (2015): 135435 3.234

  1. In-capillary self-assembly study of quantum dots and protein using fluorescence coupled capillary electrophoresis

Wang JH, Li JY, Li JC, Qin YQ, Wang CL, Qiu L and Jiang PJ*

Electrophoresis (2015)36: 1523-1528 3.028

  1. Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells

Li T, Xu XH, Tang ZH, Wang YF, LEUNG CH, Dik-lung MA, Chen XP, Wang YT, Chen Y and Lu JJ*

Acta Pharmcol. Sin. (2015)36: 1503-1513 2.912

  1. AT 101 inhibits hedgehog pathway activity and cancer growth

Wang J, Peng YQ, Liu Y, Yang J, Huang M and Tan WF*

Cancer Chemoth. Pharm. (2015)76: 461-469 2.769

  1. Efficient separation of curcumin, demethoxycurcumin, and bisdemethoxycurcumin from turmeric using supercritical fluid chromatography: From analytical to preparative scale

Song W, Qiao X, Liang WF, Ji S, Yang L, Wang Y, Xu YW, Yang Y, Guo DA and Ye M*

J. Sep. Sci. (2015)38(19): 3450-3453 2.737

  1. Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells

Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL, Zhu H, Chen XP, Wang YT, Chen Y and Lu JJ*

Eur. J. Pharmacol. (2015)749: 81-88 2.532

  1. Development of a Novel Phosphorylated AMPK Protection Assay for High-Throughput Screening Using TR-FRET Assay

Xu YZ, Wang YJ, Xu Y, Li J, Liao H*, Zhang LY* and Pang T*

J. Biomol. Screen. (2015)20(7): 906-912 2.423

  1. Synthesis of (±)-Pterocarpin and Its Thia- and Aza-Analogues in a Modular Manner

Huang QY, Wang P, Tian Y, Ni Song, Ren SM, Tao JX, Hang KN and Li M*

Synlett (2015)26: 1385-1390 2.419

  1. Galiellalactone analogs and their possible precursors from Sarcosomataceae

Tian JF, Yu RJ, Li XX, Gao H, Guo LD, Li Y, Li J, Tang JS* and Yao XS*

Fitoterapia (2015)101: 92-98 2.345

  1. Three new compounds from the bark of Antiaris toxicaria

Li XS, Zhu JJ, Zhao H, Li SL, Hao XJ, Yao XS and Tang JS*

Phytochem. Lett. (2015)13: 182-186 1.45

  1. Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B

Fu XZ, Zhang MM, Gao Q, Yang FL, Li YX and Ding N*

J. Carbohyd. Chem. (2015)34(8): 445-459 1.417

  1. Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells

Li J, Feng J, Luo C, Sung, Herman Ho-Yung and Jiang RW*

Chin. J. Nat. Medicines. (2015)13: 59-64 1.114

  1. 膜超极化激活离子通道及其靶向抗癫痫药物研究进展

孙智明,黄卓*

药学进展 2015(2): 98-104 核心期刊

  1. 三颗针抗菌活性成分研究

徐婵,吴潇潇,万定荣,王强,吕静南,黄密,杨新洲*

华中科技大学学报(医学版) (2015)5: 556-562 核心期刊 

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